Nikola Z. 
Destroy All Humans 2 Reprobed is a remade version of the original game. In this game, you have better graphics, newer gameplay features and mechanics. With this new remade game, players can experience the brand new ending and the improved final boss that they will fight.
This guide will show you the ending and how to defeat the final boss in Destroy All Humans 2 Reprobed.
Final Boss Guide & Ending – Destroy All Humans 2 Reprobed
The ending will begin once you finally stumble upon Natalya who is trapped in a bubble and cannot get out. You will also meet up with Milenkov, your former enemy who will run away from you after your short conversation.
You will save Natalya and let Milenkov run away. This is the time where you begin your space travel and start to look for Milenkov.
Your next objective will be to protect Natalya until she finishes injecting the virus in Milenkov’s base.
After the virus has been successfully injected inside the base, it will begin to explode. You and Natalya will fly off into the distance to a safe area.
Milenkov will then come to you and shoot down Natalya. He will then turn into a savage monster which is the final boss of the game.
The final boss has a few attacks that he will perform on you.
The first attack will be a basic charge and slam mechanic. Simply jump away and dodge this attack.
Milenkov also has a red laser beam that will be shot directly toward you. Try to run close to him as much as possible to dodge this attack.
Above his head, Milenkov has a snail-looking weapon that will shoot out green blobs that will damage you. The same ones will be also shot out of his hands. To avoid this mechanic, just try to dodge where they are coming.
Another mechanic that this boss will perform is where he spawns a green laser beam from the sky that will begin to follow you. Run away from this laser until it fades away.
You will notice that as you attack this boss, his health will not go down. Reason behind this is all of that armor that he is wearing. Continue to attack him as much as you can until you notice his armor breaking apart.
Once the armor has broken apart, your next job is to continue damaging the boss until he dies. After 50% has been depleted, you will enter a cut-scene where Milenkov will be zapped in the chest and explode.
And just like that, you will defeat the final boss in Destroy all Humans 2 Reprobed and enter the final Cut-Scene.
